Everything about Salbutamol totally explained
| PubChem = 2083
| DrugBank = APRD00553
| C=13 | H=21 | N=1 | O=3
| molecular_weight = 239.311
| bioavailability =
| protein_bound =
| metabolism =
Hepatic
| elimination_half-life = 1.6 hours
| excretion =
Renal
| pregnancy_AU = A
| pregnancy_US = C
| pregnancy_category =
| smiles = HOc1c(CHO)cc(C(HO)NC(C)(C)(C))cc1
| legal_AU = S3
| legal_CA =OTC
| legal_UK = POM
| legal_US = Rx-only
| legal_status =
| routes_of_administration = Oral, inhalational,
IV
}}
Salbutamol (
INN) or
albuterol (
USAN) is a short-acting
β2-adrenergic receptor agonist used for the relief of
bronchospasm in conditions such as
asthma and
chronic obstructive pulmonary disease.
Salbutamol sulfate is usually given by the inhaled route for direct effect on bronchial smooth muscle. This is usually achieved through a
metered dose inhaler (MDI),
nebuliser or other proprietary delivery devices (for example
Rotahaler or
Autohaler). In these forms of delivery, the maximal effect of Salbutamol can take place within five to twenty minutes of dosing, though some relief is immediately seen. Salbutamol can also be given orally as an
inhalant or
intravenously. However, some asthmatics don't have the required DNA base sequence in a specific gene and may not respond to these medications.
Salbutamol became available in the
United Kingdom in
1969 and in the
United States in
1980 under the trade name Ventolin.
Clinical use
Salbutamol is specifically indicated in the following conditions:
As a β
2-agonist, salbutamol also finds use in
obstetrics. Intravenous salbutamol can be used as a
tocolytic to relax the
uterine smooth muscle to delay
premature labour. Whilst preferred over agents such as
atosiban and
ritodrine, its role has largely been replaced by the calcium-channel blocker
nifedipine which is more effective, better tolerated and orally administered.
Diet and bodybuilding use
Salbutamol is taken by some as an alternative to
Clenbuterol for purposes of fat burning.
Ban of CFC-containing albuterol inhalers
The U.S. Food & Drug Administration in April of 2005 mandated that all (including albuterol) inhalers containing
chlorofluorocarbons (CFCs) will be prohibited in the United States as of 12/31/2008. CFC inhalers had previously been given "essential use" status, exempting it from a CFC-production ban, however in accordance with the Montreal Protocol that'll be phased out; in many other countries patients have been transitioned to non-CFC based (HFA) inhalers. Pharmaceutical manufacturers are expected to produce adequate supplies of alternative (HFA) inhalers by 2009.
One drawback of this transition to HFA inhalers is that due to patent restrictions all of the HFA albuterol inhalers are "brand-name" (ProAir, Proventil, and Ventolin). They cost approximately $20 more per inhaler than existing generic CFC albuterol inhalers. Generic HFA albuterol inhalers are not expected on the market until 2017 due to existing patents, although some pharmaceutical companies will offer discounts for those who can't afford the HFA inhalers.
Benefits of transitioning to HFA inhalers include (1) increased drug deposition in the distal airways, (2) more consistent drug delivery from nearly empty canisters, and (3) more consistent drug delivery at a greater range of canister temperatures. It should be noted that the spray force of HFA inhalers is less than that of CFC inhalers, which may mislead some patients to believe that they may not be receiving enough albuterol when in fact they're seeing the benefits as outlined above.
Further Information
Get more info on 'Salbutamol'.
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